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PhD Position Brain Cancer Research
Frankfurt am Main
Aktualität: 27.03.2024

Anzeigeninhalt:

27.03.2024, Universitätsklinikum Frankfurt
Frankfurt am Main
PhD Position Brain Cancer Research
We are seeking a motivated and dedicated PhD student to: Generate glioblastoma organoids from relapsed tumor samples, Optimize organoid culture protocols to ensure robust and standardized organoid formation, Co-culture patient-derived organoids with autologous immune cells and genetically engineered CAR-NK cells targeting specific tumor antigens, Evaluate treatment efficacy and responses in HER2-positive glioblastoma patients using established organoid model. Generation of personalized and humanized mice: intracranial injection of patient-derived organoids into mouse xenografts along with human immune system reconstitution.
Hold - or will obtain before start of the position - a master degree in immune biologie, biomedicine or a related field. Demonstrate exceptional academic achievements throughout your Bachelor's and Master's studies. Possess relevant expertise in organoid culture techniques, immune cell biology and animal experiments (FELASA B) Are fluent in academic English (speaking and writing). Proficiency in German advantageous but not mandatory. Exhibit strong motivation to pursue a doctoral degree with this impactful project. Additional Desirable Qualifications: Preference will be given to candidates with: Proven ability to work independently and collaboratively in research environment. Effective Communication and presentation skills. Strong problem-solving skills and a proactive approach to research challenges. Previous experience in cancer research, particularly with a focus on glioblastoma and immunotherapy. Due to legal regulations, a valid proof of measles immunity / measles vaccination required.

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